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GHK-Cu (COPPER PEPTIDE)

What Is GHK-Cu?

GHK-Cu is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) that binds copper ions (Cu²⁺). It was first discovered in human plasma and is present in higher amounts in young people, declining with age. The synthetic version used in wellness is the copper-bound form (GHK-Cu), which is highly stable and bioactive.

It’s available in two main forms:

  • Topical (creams, serums, scalp solutions) — most common for skin, hair, and localized repair.

  • Injectable (subcutaneous) — used for more systemic regenerative effects.

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How Does GHK-Cu Work?

GHK-Cu acts as a powerful signaling molecule that influences gene expression and cellular behavior. Its main mechanisms include:

  • Modulates Gene Expression Resets over 4,000 human genes toward a “youthful” pattern (based on DNA microarray studies). It upregulates repair genes and downregulates inflammatory and destructive ones.

  • Stimulates Collagen, Elastin & Glycosaminoglycan Production Increases synthesis of structural proteins and hyaluronic acid → thicker, more elastic skin and stronger connective tissue.

  • Powerful Antioxidant & Anti-Inflammatory Effects Boosts superoxide dismutase (SOD) and other antioxidant enzymes. Reduces pro-inflammatory cytokines (IL-6, TNF-α) and NF-κB activity → calms chronic low-grade inflammation.

  • Promotes Wound Healing & Tissue Remodeling Enhances angiogenesis (new blood vessel formation), attracts repair cells (fibroblasts, stem cells), and improves extracellular matrix quality → faster, better-quality healing with less scarring.

  • Copper Delivery at the Cellular Level Safely transports copper into cells where it’s needed for enzyme function, DNA repair, and mitochondrial health—without causing copper overload in most cases.

Potential Benefits

Skin & Anti-Aging (Strongest Evidence – Mostly Topical Studies)

  • Increases skin thickness, firmness, and elasticity

  • Reduces fine lines, wrinkles, and photoaging damage

  • Improves skin barrier function and hydration

  • Fades hyperpigmentation and improves overall tone

  • Accelerates healing of wounds, burns, ulcers, and post-procedure recovery

Hair & Scalp Health

  • Stimulates hair follicle growth and thickness

  • May reduce inflammation-related hair loss (e.g., androgenetic alopecia support)

  • Often combined in scalp solutions for thinning hair or maintenance

Wound & Tissue Repair

  • Faster healing of surgical incisions, tendon/ligament injuries, and chronic wounds

  • Better collagen organization → stronger, more flexible scar tissue

  • Support for joint, cartilage, and connective tissue integrity

Systemic / Regenerative Effects (Injectable Use – Emerging Research)

  • Reduced systemic inflammation markers

  • Improved antioxidant defenses

  • Support for lung, liver, and nerve tissue protection (preclinical)

  • Potential benefits in age-related decline of tissue resilience

Many users report visible skin improvements within 4–12 weeks (topical) and more gradual systemic effects (injections) over 2–6 months.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. All peptides are compounded formulations and not FDA-approved. Consult your healthcare provider before use.

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