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AOD-9604

What Is AOD 9604?

AOD 9604 is a synthetic peptide made up of the first 16 amino acids (residues 177–191) of the C-terminal fragment of human growth hormone (hGH). This specific portion is believed to be responsible for hGH's fat-metabolizing (lipolytic) effects without triggering the growth-promoting or insulin-like actions of full-length growth hormone.

 

How Does AOD 9604 Work?

Unlike full growth hormone or GHRH analogs (Sermorelin, Tesamorelin), AOD 9604 focuses narrowly on fat metabolism:

  • Stimulates Lipolysis (Fat Breakdown) Activates hormone-sensitive lipase in fat cells → breaks down stored triglycerides into free fatty acids and glycerol so they can be burned for energy.

  • Inhibits Lipogenesis (Fat Formation) Reduces the creation of new fat by interfering with fat storage pathways in adipocytes.

  • Targets Fat Without Affecting Growth or IGF-1 Unlike full hGH, AOD 9604 does not significantly raise IGF-1 levels, does not promote muscle or bone growth, and has minimal impact on insulin sensitivity or blood sugar in most studies.

  • No Major Hormonal Disruption It avoids the broader endocrine effects of growth hormone (no suppression of natural GH production, minimal influence on thyroid, cortisol, or prolactin).

​​Potential Benefits 

  • Targeted Fat Reduction

    • Preference for reducing abdominal and visceral fat (deep belly fat)

    • Helps with stubborn areas that resist diet and exercise alone

  • Improved Body Composition

    • Gradual decrease in body fat percentage

    • Better waist circumference and overall appearance when combined with lifestyle changes

  • Support During Weight Management

    • Useful as an adjunct in calorie-restricted or ketogenic protocols

    • May help preserve lean muscle mass while fat is lost

  • Metabolic Health Support

    • Potential mild improvement in lipid profiles (cholesterol/triglycerides)

    • Some users report better energy stability during fat-loss phases

  • Minimal Side Effect Profile

    • Generally well-tolerated with fewer systemic effects than full GH therapies

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. All peptides are compounded formulations and not FDA-approved. Consult your healthcare provider before use.

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