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VIP (vasoactive intestinal peptide)

VIP is a 28-amino-acid neuropeptide naturally produced in the gut, brain, lungs, and immune cells. It acts as both a neurotransmitter and a hormone, with receptors (VPAC1 and VPAC2) found throughout the body — especially in the brain, lungs, gut, and immune tissues.

In wellness and functional medicine protocols, synthetic VIP is typically administered as a nasal spray (most common in CIRS/mold protocols) or sometimes via injection. It’s prized for its ability to restore balance in systems that have been thrown off by chronic inflammation or biotoxin exposure

Potential Benefits

VIP is most discussed in the context of Chronic Inflammatory Response Syndrome (CIRS) from mold/water-damaged buildings, MCAS, post-viral syndromes, or multi-system inflammatory states. Common reported areas include:

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  • Reduced Systemic Inflammation & Fatigue

    • Less “wired but tired” feeling

    • Improved energy and reduced post-exertional malaise

  • Better Brain Fog, Mood & Cognitive Function

    • Clearer thinking, less mental fatigue

    • Support for anxiety/depression tied to inflammation

  • Mast Cell & Histamine Symptom Relief

    • Fewer flushing episodes, hives, or allergic-like reactions

    • Calmer histamine responses

  • Improved Autonomic Balance (POTS-like Symptoms)

    • Better heart rate regulation, less orthostatic intolerance

    • Improved exercise tolerance over time

  • Gut & Immune Support

    • Stronger gut barrier

    • Fewer GI flares or IBS-like symptoms

  • Sleep & Circadian Rhythm Help

    • Better rest and recovery (via parasympathetic support)

  • Many people in CIRS or mold protocols report VIP helps with the “last piece” — when symptoms persist even after remediation and other steps. Benefits often build gradually over 3–9 months with consistent use.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. All peptides are compounded formulations and not FDA-approved. Consult your healthcare provider before use.

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